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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE1A
All Species:
30.91
Human Site:
Y181
Identified Species:
75.56
UniProt:
P54750
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54750
NP_001003683.1
535
61252
Y181
H
S
L
K
F
M
I
Y
E
L
F
T
R
Y
D
Chimpanzee
Pan troglodytes
XP_515959
553
63273
Y181
H
S
L
K
F
M
I
Y
E
L
F
T
R
Y
D
Rhesus Macaque
Macaca mulatta
XP_001101568
545
62242
Y181
H
S
L
K
F
M
I
Y
E
L
F
T
R
Y
D
Dog
Lupus familis
XP_532505
595
67382
D196
H
N
L
M
H
A
A
D
V
T
Q
T
V
H
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q61481
565
64452
Y201
H
S
L
K
F
M
I
Y
E
L
F
T
R
Y
D
Rat
Rattus norvegicus
Q63421
768
86653
Y250
H
A
L
K
F
I
F
Y
E
L
L
T
R
Y
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515772
621
69800
Y181
H
S
L
K
F
M
M
Y
E
L
F
T
R
Y
D
Chicken
Gallus gallus
XP_421969
641
72641
Y166
H
S
L
K
F
M
M
Y
E
L
F
T
R
Y
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692892
625
71088
Y184
H
A
L
K
F
L
V
Y
E
L
L
T
R
Y
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O18696
664
74836
F295
H
A
L
K
Y
V
G
F
E
L
F
N
R
Y
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.1
95.2
60.5
N.A.
87.6
48.1
N.A.
72.3
65.9
N.A.
60.9
N.A.
N.A.
N.A.
39.3
N.A.
Protein Similarity:
100
96.3
95.9
73.6
N.A.
91.6
59.5
N.A.
79.7
73.3
N.A.
72.1
N.A.
N.A.
N.A.
55.7
N.A.
P-Site Identity:
100
100
100
20
N.A.
100
73.3
N.A.
93.3
93.3
N.A.
73.3
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
100
100
100
33.3
N.A.
100
86.6
N.A.
100
100
N.A.
93.3
N.A.
N.A.
N.A.
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
30
0
0
0
10
10
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
80
% D
% Glu:
0
0
0
0
0
0
0
0
90
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
80
0
10
10
0
0
70
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% G
% His:
100
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% H
% Ile:
0
0
0
0
0
10
40
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
90
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
100
0
0
10
0
0
0
90
20
0
0
0
0
% L
% Met:
0
0
0
10
0
60
20
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
90
0
0
% R
% Ser:
0
60
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
10
0
90
0
0
0
% T
% Val:
0
0
0
0
0
10
10
0
10
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
80
0
0
0
0
0
90
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _